Pathophysiology of the AKI to CKD Transition: Understanding Mechanisms of Injury & Disease Progression
Time: 2:00 pm
day: Day One Track 1 PM
Details:
- An overview of the AKI-to-CKD transition, highlighting the unmet need through epidemiological insights, patient tracking data, and the challenges in translating preclinical findings to human disease.
- Exploration of key mechanisms driving maladaptive repair, including cellular senescence, mitochondrial dysfunction, and persistent inflammation that contribute to CKD progression post-AKI.
- Discussion of clinical development challenges, such as trial design, patient selection, and endpoint validation, alongside potential opportunities for repurposing therapies and targeting maladaptive repair pathways.
