Fireside Chat: Navigating the Multi-Drug Treatment Landscape in CKD: Understanding the Implications on Drug Discovery & Development to Inform Future Directions
Time: 8:00 am
day: Day One AM
Details:
As the chronic kidney disease treatment landscape evolves, marked by significant breakthroughs such as SGLT2i, GLP-1s, ACEi/ARBs, MRAs, the field is rapidly advancing toward more effective multi-drug therapies. However, these advancements present new challenges and considerations for drug discovery, development, and clinical trial design. This panel will explore the complexities of leveraging these successes to fuel future innovation while addressing critical hurdles related to endpoint selection, composite markers, and long-term therapeutic outcomes
- Evaluating how the success of SGLT2i, GLP-1s, ACEi/ARBs, MRAs reshapes the CKD treatment paradigm and the implications for discovering new therapeutic targets
- Examining the complexities of designing trials in a crowded therapeutic landscape—how do we integrate new treatments without compromising patient safety and trial validity?
- What are the next steps in CKD drug discovery, considering the saturation of existing treatment modalities? How do we ensure that innovation keeps pace with the changing standard of care while addressing unmet needs?