Dustin Little

Company: AstraZeneca

Job title: Global Clinical Lead

Seminars:

Designing Clinical Trials to Demonstrate Superiority Over Robust Standards of Care to Breakthrough the Plateau 1:30 pm

Explore alternative endpoints to reveal incremental benefits when standard clinical markers indicate limited room for progress, such as using patient-reported outcomes or advanced biomarkers to capture subtler treatment effects Evaluate novel trial designs like adaptive trials or crossover studies that allow flexibility in assessing superiority over the standard of care, potentially enhancing statistical power and…Read more

day: Day One Track 2 PM

Mastering Hierarchical Composite Endpoints: Challenges & Opportunities in CKD Trials 1:30 pm

Hierarchical composite endpoints (HCEs) combine multiple clinical and surrogate endpoints in a single trial, providing a pathway to demonstrate efficacy across various outcomes in CKD trials. However, the complexity of developing, ranking, and interpreting HCEs presents unique challenges, especially in CKD trials where surrogate endpoints such as proteinuria or GFR slope play a critical role.…Read more

day: Pre-Conference Workshop C