Development of Balcinrenone/Dapagliflozin Combination in Chronic Kidney Disease

  • Pre-clinical efficacy of balcinrenone, a novel MRA with a differentiated mode of action
  • In phase 2 trials, balcinrenone/dapagliflozin was safe and reduced albuminuria in patients with CKD, with minor impacts on serum potassium levels
  • Phase 3 development in heart failure and CKD