Advancing Kidney-Targeted RNA Therapies to Overcome Delivery Barriers & Unlock New Renal Biology

• Harnessing endogenous kidney recycling receptors such as megalin to deliver ligand-siRNA conjugates selectively to proximal tubule epithelial cells and achieve durable gene silencing in the kidney
• Targeting solute carrier proteins and other disease-modifying genes within specific renal cell populations to expand the range of biology accessible to oligonucleotide therapeutics
• Extending receptor-mediated delivery beyond the proximal tubule into additional kidney cell types and diseases to build a broader platform for precision RNA medicines in renal and systemic disease

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