Kidney-Targeted LNP Delivery as a Next-Generation Therapeutic for ADPKD: Challenges, Design & Translational Path
- Strategies for achieving kidney tropism: tuning size, charge, PEGylation, and reabsorption pathways
- Balancing efficacy, immunogenicity, and safety in nonviral LNP delivery for renal cells
- Integrating EPIC-Cure design with LNP payloads to minimize off-target effects in ADPKD
- Path to translation: scale-up, regulatory considerations, and metrics for success in ADPKD clinical trials