Leveraging Hierarchical Composite Endpoints to Capture Meaningful Outcomes in CKD Trials

• Defining the role of hierarchical endpoints in addressing heterogeneity in CKDoutcomes
• Designing trials that balance regulatory rigor with clinical relevance
• Case examples of composite endpoint application in recent CKD studies
• Best practices and pitfalls when perationalizing hierarchical outcome measures

Speakers:

Dustin Little

Global Clinical Lead

AstraZeneca