Roundtable Discussion: Models & Assays for PKD: Organoids, Rodents, EV-Based Diagnostics, and AI Tools
- Using human kidney organoids and zebrafish or C. elegans models for early screening of therapeutic targets and cystogenesis assays
- Developing EV-based urine assays to detect polycystin-1/2 levels and prognosticate disease before significant cyst development
- Applying AI-enabled imaging tools and organoid video analysis platforms (e.g. “Organoid Tracker”) to quantify cyst formation rate, growth velocity, morphology
- Standardizing rodent PKD model cores (e.g. varying progression rates) to allow cross-study comparability and better translational predictivity