Alexander Duncan
Seminars
Thursday 18th March 2027
Learning Across Proteinuric Kidney Diseases to Translate Shared Mechanisms into Disease-Modifying Therapies
3:00 pm
- Identifying shared biological drivers across FSGS, IgAN, membranous nephropathy and Alport syndrome to move beyond symptom control and develop therapies capable of modifying underlying disease biology
- Targeting podocyte injury, suPAR/uPAR signaling and cytoskeletal dysfunction to preserve glomerular filtration and kidney function across genetically and mechanistically diverse proteinuric diseases
- Using cross-indication clinical and biomarker evidence to determine where common mechanisms can support broader development strategies while preserving disease-specific patient selection and endpoints
