Alfica Sehgal
Chief Scientific Officer Judo Bio
Seminars
Wednesday 18th March 2026
Precision siRNA Delivery to the Proximal Tubule via Endogenous Receptor Targeting
1:00 pm
- Leverage endogenous receptor-mediated uptake (via megalin) to deliver ligand-siRNA conjugates directly into proximal tubule cells for high kidney exposure and gene silencing
- Achieve durable target gene knockdown (50–70%) in the kidney lasting up to four weeks from a single dose— demonstrating effectiveness of the receptor-mediated delivery strategy
- Overcome a longstanding delivery challenge by increasing siRNA accumulation in the kidney 5–30-fold compared to naked siRNA, enabling new therapeutic targets to be addressed
Wednesday 18th March 2026
Panel Discussion: How Can Novel Modalities be Used to Meet the Unmet Needs in CKD?
10:30 am
- Balancing innovation with clinical feasibility and scalable development in kidney disease
- Addressing AAV’s narrow tropism: how do we translate promise into real-world therapies?
- Exploring whether targeted delivery strategies must be disease-specific to maximize impact
- Ensuring RNAi and oligonucleotide therapies achieve durable, clinically meaningful kidney knockdown
