Ron Perrone
Professor of Medicine Tufts Medical Center
Seminars
Tuesday 17th March 2026
Making CKD Clinical Trials More Accessible, Feasible & Patient-Centered: Bridging Research Goals with Real-World Realities
5:30 pm
- Understanding the broader patient experience from both patient, caregiver and clinician perspective
- Exploring the decision to participate in a clinical trial, and factors that may limit patient involvement
- Examining strategies to make trials more accessible to patients including geographical, financial and logistical barriers, while fostering open communication between researchers and participants
- Reducing burden for patients to participate in a clinical trial through innovative strategies
Monday 16th March 2026
Balancing eGFR Decline & TKV Growth for Regulatory Endpoints in PKD
3:00 pm
- Evaluating whether TKV growth meets regulatory standards for “reasonably likely surrogate” endpoints, especially under accelerated approval pathways
- Investigating how well eGFR decline tracks patient-centered outcomes and long-term kidney failure risk compared to TKV alone
- Discussing whether combined endpoints (e.g. TKV + eGFR) offer stronger case for full approval versus accelerated or conditional approvals
- Understanding global regulatory differences (FDA, EMA, PMDA etc.) in accepting imaging- and biomarker-based endpoints, and how trials can harmonize design across jurisdictions
