Sradha Kotwal
Program Head, Renal & Metabolic Division The George Institute for Global Health
Seminars
Tuesday 17th March 2026
CAPTIVATE: Innovating Adaptive Platform Trial Design to Slow CKD Progression
12:00 pm
- Employing the Global Kidney Patient Trials Network (GKPTN) registry to pre-identify and enroll over 4,300 non-dialysis CKD patients across 8 countries, enabling more representative baseline data
- Using an adaptive platform, multifactorial, phase III trial structure allowing addition/removal of therapeutic agents and domains – starting with a mineralocorticoid receptor antagonist vs placebo
- Targeting slowing of eGFR decline as the primary endpoint, powered via Bayesian simulations to detect a clinically meaningful improvement of ~2.6 mL/min/1.73 m² over 104 weeks
- Building in flexibility through the “eternal” trial design (ongoing recruitment and follow-up), enabling testing of combination treatments and evolving interventions over time
