William newsome
Seminars
Thursday 18th March 2027
Targeting Fibrotic Remodeling After Kidney Transplantation to Preserve Graft Function & Extend Organ Survival
2:00 pm
- Defining fibrosis as a distinct driver of progressive graft dysfunction following kidney transplantation to identify patients who continue to deteriorate despite control of immune-mediated rejection
- Targeting DDR1-driven collagen sensing and maladaptive extracellular matrix remodelling to interrupt the self-sustaining fibrotic cycle while preserving the physiological repair required for normal tissue healing
- Combining protocol biopsies, molecular patient selection and early target-engagement biomarkers to translate anti-fibrotic biology into a personalised clinical development strategy and demonstrate graft preservation earlier
